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The concomitant utilization of acetaminophen and codeine phosphate tablets with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor might lead to reduced codeine levels, increased norcodeine degrees, and fewer metabolism by using 2D6 with resultant reduce morphine amounts.If concomitant use of a CYP3A4 inhibitor